The crystal and molecular structure of a valinomycin analogue cyclo[(D-Val-L-Lac-L-Ala-D-Hyi)2 (D-Val-L-Lac-L-Val-D-Hyi)] · H2O (C50H82N6O18 · H2O)

✍ Scribed by V. Z. Pletnev; S. N. Ruzeinikov; I. N. Tsigannik; V. T. Ivanov; S. V. Pletnev; D. A. Langs; W. L. Duax

• Publisher: Wiley (John Wiley & Sons)
• Year: 1997
• Tongue: English
• Weight: 156 KB
• Volume: 42
• Category: Article
• ISSN: 0006-3525
• DOI: 10.1002/(sici)1097-0282(199711)42:6<651::aid-bip4>3.0.co;2-t

✦ Synopsis

The crystal and molecular structure of the valinomycin analogue, cyclo [(D-Val-L-Lac-L-Ala-D-Hyi) 2 (D-Val-L-Lac-L-Val-D-Hyi)] has been solved by x-ray direct methods using the ''Shake and Bake'' procedure. The crystals, grown from a mixture of octane/CH 2 Cl 2 , belong to space group P2 1 (Z Å 4) with cell parameters a Å 10.29, b Å 32.08, c Å 18.73 A ˚, b Å 97.05Њ, and contain two molecules per asymmetric unit. After anisotropic refinement the standard reliability factor was R1 Å 0.058. The conformations of both independent molecules is similar to that observed for isoleucinomycin, cyclo [-(D-Ile-L-Lac-L-Ile-D-Hyi) 3 ] [V.