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Molecular Cloning of the Breakpoint Junction of a Human Chromosomal 8;14 Translocation Involving the T-Cell Receptor α -Chain Gene and Sequences on the 3′Side of MYC

✍ Scribed by Timothy W. McKeithan, Elizabeth A. Shima, Michelle M. Le Beau, Jun Minowada, Janet D. Rowley and Manuel O. Diaz


Book ID
123633434
Publisher
National Academy of Sciences
Year
1986
Tongue
English
Weight
995 KB
Volume
83
Category
Article
ISSN
0027-8424

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An (8;14)(q24;q11) translocation involvi
✍ James K. Park; Timothy W. McKeithan; Michelle M. le Beau; Mitchell A. Bitter; Wi 📂 Article 📅 1989 🏛 John Wiley and Sons 🌐 English ⚖ 796 KB

We describe a t(8; I4)(q24;q I I) involving the T-cell receptor a-chain gene (TCRA) and the 3' region of the MYC protooncogene in a B-cell lymphoma. The 6-cell origin of this tumor was determined by its histological architecture, by immunophenotypic analysis, and by Southern analysis of immunoglobul