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Molecular cloning of rat JAK3, a novel member of the JAK family of protein tyrosine kinases

✍ Scribed by Takamune Takahashi; Takuji Shirasaw


Book ID
115930271
Publisher
Elsevier Science
Year
1994
Tongue
English
Weight
919 KB
Volume
342
Category
Article
ISSN
0014-5793

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A member of a new class of protein tyrosine kinases, JAK1, has been mapped to lp31.3 by in situ hybridization and Southern blot analysis of a panel of mouse-human hybrid cell lines. A murine protein tyrosine kinase, related to, but distinct, from JAK1, was mapped by in situ hybridization to human Ch

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Genes encoding two members of the JAK family of protein tyrosine kinases, Jak-1 and Jak-2, have been mapped to mouse Chromosomes (Chrs) 4 and 19 respectively. These placements are consistent with the previously described location of human JAK1 and JAK2, which lie in regions of synteny on human Chrs