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Two members of the JAK family of protein tyrosine kinases map to Chromosomes 1p31.3 and 9p24

✍ Scribed by Melanie A. Pritchard; Elizabeth Baker; David F. Callen; Grant R. Sutherland; Andrew F. Wilks

Publisher: Springer-Verlag
Year: 1992
Tongue: English
Weight: 231 KB
Volume: 3
Category: Article
ISSN: 0938-8990
DOI: 10.1007/bf00355839

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✦ Synopsis

A member of a new class of protein tyrosine kinases, JAK1, has been mapped to lp31.3 by in situ hybridization and Southern blot analysis of a panel of mouse-human hybrid cell lines. A murine protein tyrosine kinase, related to, but distinct, from JAK1, was mapped by in situ hybridization to human Chromosome (Chr) 9p24 and lp31.3. located kinase-related domain. Such a structure is unprecedented in the PTK family, and may have significant implications for our notions of the biochemistry of signal transduction within the eukaryotic cell. Here we report the chromosomal locations of two members of the JAK family of PTKs, JAK1 (Wilks et al. 1991) and JAK2.

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