Molecular and serological diversity of anti-DNA autoantibodies from NZB and (NZB × NZW) F1 mice
✍ Scribed by Joan L. Klotz; Gretchen L. Kiser; Mitchell Kronenberg
- Book ID
- 104177099
- Publisher
- Elsevier Science
- Year
- 1988
- Tongue
- English
- Weight
- 659 KB
- Volume
- 19
- Category
- Article
- ISSN
- 0165-2478
No coin nor oath required. For personal study only.
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## Proliferation of Ly-1 B cells in autoimmune NZB and (NZB X NZW)F1 mice* Spontaneous autoimmune disease in NZB and (NZB x NZW)FI (B/W) mice is associated with a spectrum of lymphoproliferative abnormalities, but the relationship between autoimmunity and lymphoproliferation is poorly understood.
## Abstract Immunization of NZB and A/J mice against an anti‐DNA hybridoma antibody (F227) derived from (NZB x NZW)F~1~ (B/W) mice allowed the preparation of two anti‐idiotype antisera. These two reagents were shown to recognize different idiotopes of the F227 monoclonal antibody. NZB anti‐idiotypi
## Abstract Anti‐nuclear antibodies could be demonstrated in sero‐negative patients with immune complex glomerulonephritis by means of an acid dissociation method. The antibodies were also found in sero‐negative NZB and (NZB × NZW) F~1~ mice with complex glomerulonephritis. It is suggested that t