Autoantibodies to anti-DNA with anti-allotypic and anti-idiotypic specificities in (NZB × NZW)F1 mice
✍ Scribed by Dan Eilat; Ruth Fischel; Avinoam Zlotnick
- Book ID
- 102824142
- Publisher
- John Wiley and Sons
- Year
- 1985
- Tongue
- English
- Weight
- 813 KB
- Volume
- 15
- Category
- Article
- ISSN
- 0014-2980
No coin nor oath required. For personal study only.
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## Abstract Immunization of NZB and A/J mice against an anti‐DNA hybridoma antibody (F227) derived from (NZB x NZW)F~1~ (B/W) mice allowed the preparation of two anti‐idiotype antisera. These two reagents were shown to recognize different idiotopes of the F227 monoclonal antibody. NZB anti‐idiotypi
## Abstract Anti‐nuclear antibodies could be demonstrated in sero‐negative patients with immune complex glomerulonephritis by means of an acid dissociation method. The antibodies were also found in sero‐negative NZB and (NZB × NZW) F~1~ mice with complex glomerulonephritis. It is suggested that t