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Molecular and cytogenetic studies of a patient with philadelphia-negative, BCR-positive chronic myeloid leukemia and t(12;12)(q13;p12)

✍ Scribed by Dr. Alfonso Zaccaria; Nicoletta Testoni; Angela Tassinari; Bommina Celso; Beverly S. Emanuel; Marcia Budarf; Giuseppe Saglio; Angelo Guerrasio; Cosimo Barletta; Cesare Peschle; Sante Tura

Publisher: John Wiley and Sons
Year: 1990
Tongue: English
Weight: 443 KB
Volume: 1
Category: Article
ISSN: 1045-2257
DOI: 10.1002/gcc.2870010405

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✦ Synopsis

A patient with Philadelphia (Phi)-negative. breakpoint cluster region (bcr)-positive chronic myeloid leukemia (CML) is reported. Pulsed-field gel electrophoretic analysis demonstrated the comigration of both ABL and BCR sequences on the same BsMll and Sad1 fragment. Moreover, in situ hybridization studies demonstrated that ABL sequences had been moved from band 9q34 to 22q I I and that the additional t ( 12; I2)(q I 3;p 12) was not involved in the ABUBCR related translocation. Nevertheless, a possible role of oncogenes or regulatory sequences activated or inhibited by the additional translocation cannot be excluded.

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