Molecular and crystal structures of some novel derivatives of 3-aryl-7-arylidene-3,3a,4,5,6,7-hexahydroindazoles
✍ Scribed by V. V. Abakumov; S. V. Shishkina; R. I. Zubatyuk; I. M. Gella; N. S. Pivnenko; L. A. Kutulya; O. V. Shishkin
- Book ID
- 111437736
- Publisher
- SP MAIK Nauka/Interperiodica
- Year
- 2007
- Tongue
- English
- Weight
- 279 KB
- Volume
- 52
- Category
- Article
- ISSN
- 1063-7745
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## Abstract A novel series of 7‐benzylidene‐3, 3a, 4, 5, 6, 7‐hexahydro‐3‐phenyl‐2__H__‐indazole substituted at the 2‐position were synthesized. The reaction of 2, 6‐bis‐benzylidenecyclohexanone (**1**) with thiosemicarbazide in the presence of NaOH afforded a mixture of the 3‐H, 3a‐H __trans__ **2
## Abstract Starting from (3R)‐3‐methylcyclohexanone, compounds (III), (V) and a range of alkyl‐substituted analogues are prepared stereoselectively in low to medium yields for application as chiral additives in liquid crystalline materials.
The reaction of 2,6-diarylidenecyclohexanones with hydrazine hydrate in glacial acetic acid resulted in the formation of diastereomers of (E)-2-acetyl-3-aryl-7-arylidene-3,3a,4,5,6,7-hexahydroindazoles. The relative conÐgurations of these diastereomers were unambiguously assigned using 1H and 13C NM