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Molecular analysis ofHLA-B39subtypes

✍ Scribed by Noriko Kato; Sachiko Karaki; Kouichi Kashiwase; Claudia Müller; Tatsuya Akaza; Takeo Juji; Kyoichi Kano; Masafumi Takiguchi

Publisher
Springer-Verlag
Year
1993
Tongue
English
Weight
391 KB
Volume
37
Category
Article
ISSN
0093-7711

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✦ Synopsis

Serological studies have suggested the presence of a new HLA-B39 subtype (B39.2) in the Japanese population. To identify the new HLA-B39 subtype and compare it with an other HLA-B39 subtype (B39.1), the genes encoding HLA-B39.1 (B'39013) and B39.2 (B'3902) have been cloned from Japanese. We have sequenced these genes and completed the sequence of HLA-B39.1 (B'39011) gene from a Caucasian that was partially sequenced. Comparison of the sequence data revealed that B'3902 and B'39013 differ by three nucleotide substitutions which result in a two amino acids change at residues 63 and 67, while one silent substitution at codon 312 is found between B'39011 and B'39013. These results suggest that B'3902 has evolved from B'39013 rather than B'39011.

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