MOLECULAR ANALYSIS OF P16Ink4/CDKN2 AND P15Ink4B/MTS2 GENES IN PRIMARY HUMAN TESTICULAR GERM CELL TUMORS
β Scribed by HEIDENREICH, AXEL; GADDIPATI, JAYA P.; MOUL, JUDD W.; SRIVASTAVA, SHIV
- Book ID
- 122804334
- Publisher
- Lippincott Williams and Wilkins
- Year
- 1998
- Tongue
- English
- Weight
- 979 KB
- Volume
- 159
- Category
- Article
- ISSN
- 0022-5347
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Cyclin-dependent kinillre-4 inhibitor genes (INK4) regulate the cell cycle and are candidate tumor-suppressor genes. To determine if alterations in the coding regions of the p18 and p l 9 genes, which are novel members of the INK4 family and if they correlate with the development of human cancer, 10
## Abstract Cyclin and cyclinβdependent kinase (a) complexes play important roles in modulating the cell cycle. The CDK inhibitors (a) inhibit the kinase activities of these complexes and block the cell cycle. The __p16__/multiple tumor suppressor (__MTS__) 1/inhibitor of CDK4 (__INK4__) a/__CDKN2_