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Molecular analysis of genetic changes in ependymomas

✍ Scribed by Emilia K. Bijlsma; Annet M. J. Voesten; Engelien H. Bijleveld; Dirk Troost; Andries Westerveld; Philippe Mérel; Gilles Thomas; Dr. Theo J. M. Hulsebos

Publisher
John Wiley and Sons
Year
1995
Tongue
English
Weight
488 KB
Volume
13
Category
Article
ISSN
1045-2257

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✦ Synopsis

Ependymomas are glial cell-derived tumors. They are, in contrast t o other gliomas (astrocytomas, oligodendrogliomas, and oligoastrocytomas), ill-defined with respect t o the genes and chromosomal segments important in their tumorigenesis. In this study, we extensively screened I 7 ependymomas for genetic changes characteristic of other gliomas. Allelic loss was detected on chromosome arm 22q in three tumors; on chromosome 10 in two tumors; on chromosome arm 17p in two tumors; and on chromosome arms 6q, 9p, I 3q, and I9q, each in one tumor. No allelic losses were found on chromosome arms I p and I6q.

None of the tumors had EGFR gene amplification. In each case, the chromosomal segment affected by the deletion included the region known t o harbor a tumor suppressor gene important in glioma tumorigenesis. We conclude that ependymomas resemble the other glial neoplasms with respect t o type and location of the chromosomal changes involved. Given the relatively infrequent occurrence of these genetic changes, ependymomas should be considered genetically as low-grade gliomas. Genes

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