The multistep nature of carcinogenesis has been repeatedly demonstrated for a variety of human cancers. Concomitant mutational activation of genes that promote cellular growth (i.e., oncogenes) and inactivation of genes that normally act to restrict or otherwise regulate growth (i.e., tumor suppress
Molecular genetic alterations on chromosomes 11 and 22 in ependymomas
✍ Scribed by Katrin Lamszus; Lenard Lachenmayer; Uta Heinemann; Lan Kluwe; Ulrich Finckh; Wolfgang Höppner; Dimitrios Stavrou; Regina Fillbrandt; Manfred Westphal
- Publisher
- John Wiley and Sons
- Year
- 2001
- Tongue
- French
- Weight
- 247 KB
- Volume
- 91
- Category
- Article
- ISSN
- 0020-7136
No coin nor oath required. For personal study only.
📜 SIMILAR VOLUMES
Ependymomas are glial tumors of the brain and spinal cord occurring both sporadically and in a familial syndrome, neurofibromatosis type 2 (NF2). Previous analyses performed on specimens obtained predominantly from adult patients have shown loss of DNA sequences from chromosome arm 22q, which is the
Several genes, most of them unknown, of the short arm of chromosome 8 are involved in malignant diseases. Numerous studies have implicated a portion of the 8p11-p21 region as the location of one or more tumor suppressor genes involved in a variety of human cancers, including breast cancer. We and ot
## Abstract Allelic imbalance (AI) on chromosome arm 22q has been detected in 20%–40% of colorectal cancers, suggesting that this chromosome arm has a tumor‐suppressor gene involved in colorectal carcinogenesis. Recently, we isolated a candidate tumor‐suppressor gene, __MYO18B__, at 22q12.1, that i
Proteins of the cadherin family regulate cellular adhesion and motility and are believed to act as tumour suppressors. Previous studies have identified frequent mutation and allelic inactivation of the E-cadherin (cadherin-1) locus in diffuse gastric cancer. At least two other cadherin genes, P-cadh
Schwannomatosis is characterized by multiple peripheral and cranial nerve schwannomas that occur in the absence of bilateral 8th cranial nerve schwannomas. The latter is the main diagnostic criterion of neurofibromatosis type 2 (NF2), which is a related but distinct disorder. The genetic factors und