𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Molecular analysis of chromosomh 1 abnormalities in human gliomas reveals frequent loss of 1p in oligodendroglial tumors

✍ Scribed by M. Josefa Bello; Jesus Vaquero; Jose M. De Campos; M. Elena Kusak; Jose L. Sarasa; Javier Saez-Castresana; Angel Pestana; Juan A. Rey

Book ID
102865631
Publisher
John Wiley and Sons
Year
1994
Tongue
French
Weight
649 KB
Volume
57
Category
Article
ISSN
0020-7136

No coin nor oath required. For personal study only.

✦ Synopsis

Alterations of the short arm of chromosome I are recurrently found in cytogenetic analysis of malignant gliomas, and deletions of 1 ~3 6 . ~3 2 region characterize at least the higher-grade tumors, glioblastorna multiforme. Molecular analysis of tumorderived and normal genomic DNA from 57 cases of gliomas, using a panel of chromosome I-specific DNA probes showed LOH in 16 tumors. Allelic losses on I p were primarily restricted to glioblastoma multiforme (2/ I I) and to tumors with a major oligodendroglial component: grade II oligodendrogliomas (6/6), grade 111 anaplastic oligodendrogliomas (5/6) and grade 11-111 mixed oligo-astrocytomas (2/3). Losses for Iq markers were detected in only I tumor (glioblastoma multiforme). Our data suggest that anomalies of I p primarily characterize oligodendrogliomas, whereas they are rare events in astrocytic tumors and indicate that a tumor-suppressor gene on I p36-p32 is involved in the development of brain tumors with oligodendroglial differentiation.

πŸ“œ SIMILAR VOLUMES

Frequent biallelic inactivation and tran
Frequent biallelic inactivation and transcriptional silencing of the DIRAS3 gene at 1p31 in oligodendroglial tumors with 1p loss
✍ Markus J. Riemenschneider; Julia Reifenberger; Guido Reifenberger πŸ“‚ Article πŸ“… 2008 πŸ› John Wiley and Sons 🌐 French βš– 670 KB

## Abstract Deletion of the short arm of chromosome 1 is common in oligodendroglial tumors and has been identified as a powerful molecular marker for response to radio‐ and chemotherapy as well as favorable prognosis. Here, we investigated a series of 59 human primary gliomas for aberrations of the

Frequent deletions of material from chro
Frequent deletions of material from chromosome arm 1p in oligodendroglial tumors revealed by double-target fluorescence in situ hybridization and microsatellite analysis
✍ Naoya Hashimoto; Daisuke Ichikawa; Yoshiki Arakawa; Kousei Date; Satoshi Ueda; Y πŸ“‚ Article πŸ“… 1995 πŸ› John Wiley and Sons 🌐 English βš– 475 KB

We undertook a cytogenetic analysis of 29 human brain tumors using double-target fluorescence in situ hybridization (FISH) and focusing on chromosome arm I p. One or more tumor suppressor genes in this arm have been suggested t o be important in a variety of neuroectodermal tumors. The series includ