𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Modulation of tumour necrosis factor-α-induced cytotoxicity by polyphenols

✍ Scribed by Solomon Habtemariam

Publisher
John Wiley and Sons
Year
1997
Tongue
English
Weight
108 KB
Volume
11
Category
Article
ISSN
0951-418X

No coin nor oath required. For personal study only.

✦ Synopsis

The effects of several aromatic compounds on tumour necrosis factor-␣ (TNF)-induced cytotoxicity in murine fibroblast L929 cells were studied. Those phenolics which bear the O-dihydroxy aromatic structure (catechols), i.e. caffeic acid, catechol, 3,4-dihydroxybenzoic acid, dopamine and noradrenaline effectively inhibited TNFinduced cytotoxicity in a concentration dependent manner. Related compounds (cinnamic acid, 3,4-dimethoxycinnamic acid, 2,4-dihydroxybenzoic acid, ferulic acid, 3-hydroxy-4-methoxybenzoic acid and phydroxybenzoic acid) which lack the catecholic functional group failed to protect cells from TNF cytotoxicity. All concentrations of catechols which effectively inhibited the TNF-induced cytotoxicity were also protective as a post treatment, suggesting an effect at some step(s) in the TNF-signal transduction pathway following receptor activation.

📜 SIMILAR VOLUMES

Effects of transforming growth factor-β1
Effects of transforming growth factor-β1 and tumour necrosis factor-α on cultured fibroblasts from skin fibroma as modulated by toremifene
✍ Cinzia Lilli; Lorella Marinucci; Silvia Bellocchio; Domenico Ribatti; Chiara Bal 📂 Article 📅 2002 🏛 John Wiley and Sons 🌐 French ⚖ 218 KB

To determine how toremifene, an anti-oestrogen triphenylethylene derivate, reduces tumour mass, we investigated its modulation of TGF-beta1 and TNF-alpha in fibroma fibroblasts. Normal and fibroma fibroblasts, isolated from patients affected by Gardner's syndrome without or with fibroma manifestatio

Andrographolide inhibits the tumour necr
Andrographolide inhibits the tumour necrosis factor-α-induced upregulation of ICAM-1 expression and endothelial-monocyte adhesion
✍ Solomon Habtemariam 📂 Article 📅 1998 🏛 John Wiley and Sons 🌐 English ⚖ 111 KB

Andrographolide, a diterpene isolated from Andrographis paniculata, has been shown to have several biological activities including analgesic, antipyretic and antiinflammatory effects. Since the upregulation of adhesion molecules expression and endothelial-leucocytes adhesion are key steps in the dev

Modulation of angiogenic vascular endoth
Modulation of angiogenic vascular endothelial growth factor by tumor necrosis factor α and interleukin-1 in rheumatoid arthritis
✍ Ewa M. Paleolog; Sylvia Young; Alison C. Stark; Richard V. McCloskey; Marc Feldm 📂 Article 📅 1998 🏛 John Wiley and Sons 🌐 English ⚖ 804 KB

## Objective: To investigate the regulation of expression of the angiogenic cytokine vascular endothelial growth factor (vegf) in rheumatoid arthritis (ra), in order to determine whether new blood vessel formation could be a potential therapeutic target in ra. ## Methods: Dissociated ra synovial

Lymphocyte and monocyte-induced motility
Lymphocyte and monocyte-induced motility of MCF-7 cells by tumor necrosis factor-α
✍ Philip M. Carpenter; Tetsuya Galanaga; Hoa P. Nguyen; John C. Hiserodt 📂 Article 📅 1997 🏛 John Wiley and Sons 🌐 French ⚖ 295 KB

A potentially important tumor-host interaction is increased tumor-cell invasiveness in response to motility factors derived from stromal and lymphoid cells. Conditioned medium of IL-2-stimulated lymphocytes and fractions enriched in either T cells, natural killer (NK) cells, or monocytes induced mot

Possible roles of nonparenchymal cells i
Possible roles of nonparenchymal cells in hepatocyte proliferation induced by lead nitrate and by tumor necrosis factor α
✍ H Shinozuka; T Ohmura; S L Katyal; A I Zedda; G M Ledda-Columbano; A Columbano 📂 Article 📅 1996 🏛 John Wiley and Sons 🌐 English ⚖ 474 KB

proliferative response of the liver to mitogens, de-A single intravenous injection of lead nitrate (LN) to pending on the capacity of the mitogens to stimulate rats induces liver cell proliferation without causing cell TNF-a production. (HEPATOLOGY 1996;23:1572-1577.) necrosis (direct hyperplasia).