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Possible roles of nonparenchymal cells in hepatocyte proliferation induced by lead nitrate and by tumor necrosis factor α

✍ Scribed by H Shinozuka; T Ohmura; S L Katyal; A I Zedda; G M Ledda-Columbano; A Columbano

Publisher
John Wiley and Sons
Year
1996
Tongue
English
Weight
474 KB
Volume
23
Category
Article
ISSN
0270-9139

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✦ Synopsis

proliferative response of the liver to mitogens, de-A single intravenous injection of lead nitrate (LN) to pending on the capacity of the mitogens to stimulate rats induces liver cell proliferation without causing cell TNF-a production. (HEPATOLOGY 1996;23:1572-1577.) necrosis (direct hyperplasia). We suggested that liver cell proliferation in this model may be triggered by the induction of liver tumor necrosis factor a (TNF-a). Be-Abbreviations: LN, lead nitrate; mRNA, messenger RNA; TNF-a, tumor that TNF-a may be involved in triggering cell proliferanecrosis factor a; NAF, nafenopin; BrdU, 5-bromo-2-deoxyuridine; ABC, avition in this type of direct hyperplasia. This suggestion din-biotin-peroxidase.

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