Andrographolide inhibits the tumour necrosis factor-α-induced upregulation of ICAM-1 expression and endothelial-monocyte adhesion

✍ Scribed by Solomon Habtemariam

• Publisher: John Wiley and Sons
• Year: 1998
• Tongue: English
• Weight: 111 KB
• Volume: 12
• Category: Article
• ISSN: 0951-418X
• DOI: 10.1002/(sici)1099-1573(19980201)12:1<37::aid-ptr186>3.0.co;2-n

✦ Synopsis

Andrographolide, a diterpene isolated from Andrographis paniculata, has been shown to have several biological activities including analgesic, antipyretic and antiinflammatory effects. Since the upregulation of adhesion molecules expression and endothelial-leucocytes adhesion are key steps in the development of inflammation, the present study examines whether andrographolide modulates these biological processes in vitro. Incubation of endothelial cells with non-toxic concentrations (0.16-16.7 g/mL) of andrographolide attenuated the tumour necrosis factor-␣ (TNF)-induced intercellular adhesion molecule-1 (ICAM-1) expression. Similar concentration ranges of andrographolide also inhibited the TNF-induced endothelial-monocyte adhesion in a concentrationdependent manner. These effects of andrographolide may account for its reported in vivo antiinflammatory activity.