Modulation of Toll like Receptor 3, 7 and 8 Expression in Hepatitis C Virus Infected Patients
β Scribed by Firdaus, Rushna; Biswas, Aritra; Saha, Kallol; Mukherjee, Anirban; Chaudhuri, Sujit; Konar, Asokananda; Chandra, Alok; Chandra Sadhukhan, Provash
- Book ID
- 122122460
- Publisher
- Elsevier
- Year
- 2014
- Tongue
- English
- Weight
- 66 KB
- Volume
- 4
- Category
- Article
- ISSN
- 0973-6883
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Hepatitis C virus (HCV) interferes with interferon (IFN)-mediated innate immune defenses. Toll-like receptor (TLR) 7 agonists robustly inhibit HCV infection. We hypothesize that HCV infection may interfere with the expression and/or function of TLR7, a sensor of single-stranded RNA. We identified re
## Abstract Hepatitis C virus (HCV) infection affects an estimated 3% of the world's population. The natural outcome of infection and the natural course of disease are highly variable. Sensing of viral singleβstranded RNA (ssRNA) by Tollβlike receptor 7 (TLR7) is likely involved in early pathogen d