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Hepatitis C virus infection decreases the expression of Toll-like receptors 3 and 7 via upregulation of miR-758

โœ Scribed by Yang, Qian; Fu, Suzhen; Wang, Jie


Book ID
125809560
Publisher
Springer Vienna
Year
2014
Tongue
English
Weight
770 KB
Volume
159
Category
Article
ISSN
1432-8798

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Hepatitis C virus (HCV) interferes with interferon (IFN)-mediated innate immune defenses. Toll-like receptor (TLR) 7 agonists robustly inhibit HCV infection. We hypothesize that HCV infection may interfere with the expression and/or function of TLR7, a sensor of single-stranded RNA. We identified re