## Abstract Dendritic cells utilize various sets of Tollβlike receptors (TLR) or cytosolic sensors to detect pathogens and evoke immune responses. In patients with hepatitis C virus (HCV) infection, a higher prevalence of various infectious diseases is reported; suggesting that innate immunity agai
Expression of Toll-like receptors in chronic hepatitis C virus infection
β Scribed by Ken Sato; Tetsuya Ishikawa; Akihiko Okumura; Taeko Yamauchi; Sayaka Sato; Minoru Ayada; Eiji Matsumoto; Naoki Hotta; Tomohiko Oohashi; Yoshitaka Fukuzawa; Shinichi Kakumu
- Book ID
- 108951239
- Publisher
- John Wiley and Sons
- Year
- 2007
- Tongue
- English
- Weight
- 209 KB
- Volume
- 22
- Category
- Article
- ISSN
- 0815-9319
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## Abstract Hepatitis C virus (HCV) infection affects an estimated 3% of the world's population. The natural outcome of infection and the natural course of disease are highly variable. Sensing of viral singleβstranded RNA (ssRNA) by Tollβlike receptor 7 (TLR7) is likely involved in early pathogen d
Hepatitis C virus (HCV) interferes with interferon (IFN)-mediated innate immune defenses. Toll-like receptor (TLR) 7 agonists robustly inhibit HCV infection. We hypothesize that HCV infection may interfere with the expression and/or function of TLR7, a sensor of single-stranded RNA. We identified re