Modulation of the synthesis and glycosylation of the glucose transporter protein by transforming growth factor-β1 in Swiss 3T3 fibroblasts
✍ Scribed by Atsuko Masumi; Yuzuru Akamatsu; Takayuki Kitagawa
- Book ID
- 115730461
- Publisher
- Elsevier Science
- Year
- 1993
- Tongue
- English
- Weight
- 867 KB
- Volume
- 1145
- Category
- Article
- ISSN
- 0005-2736
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Incubation of Swiss mouse 3T3 cells at 37°C with bovine brain-derived growth factor (BDGF) decreased the cell surface '251-EGF binding activity of these cells by 70-80%. This down-modulation of the EGF receptor by BDGF was time, temperature, and dose dependent. Scatchard plot analysis indicated that
## Abstract Transforming growth factor‐beta (TGF‐beta), a potent cytokine, modulates a wide variety of biological responses. Among its actions, TGF‐beta can augment prostaglandin synthesis in several cell types. Although TGF‐beta alone has no effect on prostaglandin production in Swiss 3T3 cells, w