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Modulation of the clozapine structure increases its selectivity for the dopamine D4 receptor

✍ Scribed by Jean-François Liégeois; Jacques Bruhwyler; Jacques Damas; Françoise Rogister; Bernard Masereel; Joseph Geczy; Jacques Delarge

Book ID
115889273
Publisher
Elsevier Science
Year
1995
Tongue
English
Weight
225 KB
Volume
273
Category
Article
ISSN
0014-2999

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✍ Van Tol, Hubert H. M.; Bunzow, James R.; Guan, Hong-Chang; Sunahara, Roger K.; S 📂 Article 📅 1991 🏛 Nature Publishing Group 🌐 English ⚖ 598 KB

Dopamine receptors belong to the family of G protein-coupled receptors. On the basis of the homology between these receptors, three different dopamine receptors (D1, D2, D3) have been cloned. Dopamine receptors are primary targets for drugs used in the treatment of psychomotor disorders such as Park