Is clozapine selective for the dopamine D4 receptor?
β Scribed by Michael J. Durcan; Greg C. Rigdon; Mark H. Norman; Philip F. Morgan
- Book ID
- 116018762
- Publisher
- Elsevier Science
- Year
- 1995
- Tongue
- English
- Weight
- 568 KB
- Volume
- 57
- Category
- Article
- ISSN
- 0024-3205
No coin nor oath required. For personal study only.
π SIMILAR VOLUMES
The D4Valine194Glycine receptor is a variant of the dopamine D4 receptor and is found in 12.5% of the Afro-Caribbean population. Glycine replaces valine at a position one amino acid away from a serine which is critical for the attachment of dopamine. To determine whether this mutation had an effect
The identification of a novel dopamine receptor subtype, referred to as the D4 receptor, which binds the atypical antipsychotic drug clozapine with high potency, has led to the initiation of a drug discovery program that aims to find novel inhibitors of this receptor subtype. A selective screening s