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Modulation of sensitivity to mitomycin C and a dithiol analogue by tempol in non-small-cell lung cancer cell lines under hypoxia

✍ Scribed by Takuma Bando; Kazuo Kasahara; Kazuhiko Shibata; Yuka Numata; Utako Heki; Hiroki Shirasaki; Kei-ichi Iwasa; Masaki Fujimura; Tamotsu Matsuda

Book ID: 112497653
Publisher: Springer-Verlag
Year: 1996
Tongue: English
Weight: 684 KB
Volume: 122
Category: Article
ISSN: 1432-1335
DOI: 10.1007/bf01203069

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We have reported the establishment of a mitomycin-C (MMC)resistant non-small-cell lung-cancer cell line, PC-9/MC4. As determined by an MlT assay, this resistant cell line was found to be 4 times more sensitive to adriamycin (ADM) than was the parental PC-9. There were no significant differences in s