## Abstract The epidermal growth factor receptor (EGFR) tyrosineโkinase inhibitor gefitinib (Iressaยฎ, ZD1839) has shown promising activity preclinically and clinically. Because comparative investigations of drugโresistant sublines with their parental cells are useful approaches to identifying the m
Establishment and Characterization of Non-small Cell Lung Cancer Cell Lines Resistant to Mitomycin C under Aerobic Conditions
โ Scribed by Shibata, Kazuhiko ;Kasahara, Kazuo ;Bando, Takuma ;Nakatsumi, Yasuto ;Fujimura, Masaki ;Tsuruo, Takashi ;Matsuda, Tamotsu
- Book ID
- 108581107
- Publisher
- Wiley (Blackwell Publishing)
- Year
- 1995
- Tongue
- English
- Weight
- 607 KB
- Volume
- 86
- Category
- Article
- ISSN
- 0910-5050
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This study describes characteristics of a human bladder cancer cell line J82/MMC that is 6-fold more resistant to mitomycin C (MMC) than the parental cells. The J82/MMC subline was isolated by repeated continuous exposures of the J82/WT cells to increasing concentrations of MMC. The J82/MMC cell lin
## Abstract Three cell lines of squamousโcell carcinoma and 3 of largeโcell carcinoma origin were investigated for the expression of differentiation markers and functional parameters (proliferation, morphology, cornified envelope formation, involucrin staining, transglutaminase activity, adhesivene