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Modulation of proto-oncogene expression by colony stimulating factors

โœ Scribed by Annick Harel-Bellan; William L. Farrar


Book ID
117057585
Publisher
Elsevier Science
Year
1987
Tongue
English
Weight
692 KB
Volume
148
Category
Article
ISSN
0006-291X

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Colony stimulating factor-1 (CSF-1) is the primary regulator of the mononuclear phagocytic lineage acting through its transmembrane tyrosine kinase receptor, CSF-1R, that is the product of the c-fms proto-oncogene. Null mutations in either the ligand or the receptor genes result in a severe osteopet