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Modulation of ligand selectivity by mutation of the first extracellular loop of the human C5a receptor

✍ Scribed by Stuart A. Cain; Trent M. Woodruff; Stephen M. Taylor; David P. Fairlie; Sam D. Sanderson; Peter N. Monk


Book ID
113992646
Publisher
Elsevier Science
Year
2001
Tongue
English
Weight
523 KB
Volume
61
Category
Article
ISSN
0006-2952

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## Abstract Previously we demonstrated by random saturation mutagenesis a set of mutations in the extracellular (EC) loops that constitutively activate the C5a receptor (C5aR) (Klco et al., Nat Struct Mol Biol 2005;12:320–326; Klco et al., J Biol Chem 2006;281:12010–12019). In this study, molecular