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Modelling of the C5a receptor by iterative mutation

✍ Scribed by J.R. Holt; P.N. Monk; D.P. Fairlie; P. Kumar Madala

Book ID
113805071
Publisher
Elsevier Science
Year
2010
Tongue
English
Weight
83 KB
Volume
47
Category
Article
ISSN
0161-5890

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## Abstract Previously we demonstrated by random saturation mutagenesis a set of mutations in the extracellular (EC) loops that constitutively activate the C5a receptor (C5aR) (Klco et al., Nat Struct Mol Biol 2005;12:320–326; Klco et al., J Biol Chem 2006;281:12010–12019). In this study, molecular