Histone deacetylases (HDACs) offer potentially attractive molecular targets for sensitizing cancers to treatment with radiation therapy. By affecting patterns of gene expression, differentiation, apoptosis, and enhanced responses to therapeutic agents may be induced in cancer cells. Here, we review
โฆ LIBER โฆ
Modulation of cellular radiation responses by histone deacetylase inhibitors
โ Scribed by Karagiannis, T C; El-Osta, A
- Book ID
- 110070438
- Publisher
- Nature Publishing Group
- Year
- 2006
- Tongue
- English
- Weight
- 161 KB
- Volume
- 25
- Category
- Article
- ISSN
- 0950-9232
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## Abstract Cytochrome P450 1A2 (CYP1A2) is constitutively expressed in the mouse liver, but the constitutive expression progressively declines to an undetectable level in isolated hepatocytes. In this study, CYP1A2 was induced in hepatocytes exposed to the histone deacetylase inhibitors trichostat
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