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Differential regulation of the Sir2 histone deacetylase gene family by inhibitors of class I and II histone deacetylases

โœ Scribed by S. Kyrylenko; O. Kyrylenko; T. Suuronen; A. Salminen

Book ID
105757622
Publisher
Springer
Year
2003
Tongue
English
Weight
334 KB
Volume
60
Category
Article
ISSN
1420-682X

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## Abstract Acetylation of histones leads to conformational changes of DNA. We have previously shown that the histone deacetylase (HDAC) inhibitor, suberoylanilide hydroxamic acid (SAHA), induced cell cycle arrest, differentiation, and apoptosis. In addition to their antitumor effects as single age