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Rational Design and Development of Radiation-Sensitizing Histone Deacetylase Inhibitors

✍ Scribed by Mira Jung; Alan Kozikowski; Anatoly Dritschilo

Publisher: John Wiley and Sons
Year: 2005
Tongue: English
Weight: 102 KB
Volume: 2
Category: Article
ISSN: 1612-1872
DOI: 10.1002/cbdv.200590118

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✦ Synopsis

Histone deacetylases (HDACs) offer potentially attractive molecular targets for sensitizing cancers to treatment with radiation therapy. By affecting patterns of gene expression, differentiation, apoptosis, and enhanced responses to therapeutic agents may be induced in cancer cells. Here, we review the drug characteristics underlying design and screening of HDAC inhibitors with a focus on radiation-sensitizing properties. Radiation-sensitizing capacities have been observed in three model systems, squamous carcinoma of head and neck origin (SQ-20B), prostate adenocarcinoma (PC-3), and breast adenocarcinoma (MCF 7). Celltype specificities in radiation-sensitizing properties have been observed. Mechanisms underlying specificity are under investigation.

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