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Modular Three-Component Solid-Phase Synthesis of Unsymmetrical Guanidines via Resin Capture of Carbodiimides †

✍ Scribed by Boguszewski, Paul A.; Rahman, Shahzad S.; Ganesan, A.


Book ID
127158161
Publisher
American Chemical Society
Year
2004
Tongue
English
Weight
62 KB
Volume
6
Category
Article
ISSN
1520-4766

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We report the synthesis of 1,4-dihydropyridines on solid support utilizing the Hantzsch condensation. Unwanted reactive impurities were removed from the desired products, by selective cleavage from solid support. The synthesis of a 272 compound library is reported using the methods described.