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Modified HPV16 E7 Genes as DNA Vaccine against E7-Containing Oncogenic Cells

✍ Scribed by Michal Šmahel; Pavel Šı́ma; Viera Ludvı́ková; Vladimı́r Vonka


Book ID
112273441
Publisher
Elsevier Science
Year
2001
Tongue
English
Weight
241 KB
Volume
281
Category
Article
ISSN
0042-6822

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✍ Koen Oosterhuis; Peter Öhlschläger; Joost H. van den Berg; Mireille Toebes; Raqu 📂 Article 📅 2011 🏛 John Wiley and Sons 🌐 French ⚖ 549 KB

To allow vaccination irrespective of HLA type, DNA vaccines encoding full-length antigens are required. However, here, we demonstrate that the immunogenicity of DNA vaccines encoding the full-length human papillomavirus (HPV) type 16 E7 and E6 proteins is highly reduced compared to vaccines encoding