Preclinical development of highly effect
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Koen Oosterhuis; Peter Öhlschläger; Joost H. van den Berg; Mireille Toebes; Raqu
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Article
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2011
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John Wiley and Sons
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French
⚖ 549 KB
To allow vaccination irrespective of HLA type, DNA vaccines encoding full-length antigens are required. However, here, we demonstrate that the immunogenicity of DNA vaccines encoding the full-length human papillomavirus (HPV) type 16 E7 and E6 proteins is highly reduced compared to vaccines encoding