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Preclinical safety evaluation of DNA vaccines encoding modified HPV16 E6 and E7

✍ Scribed by F.E. Henken; K. Oosterhuis; P. Öhlschläger; L. Bosch; E. Hooijberg; J.B.A.G. Haanen; R.D.M. Steenbergen


Book ID
116964907
Publisher
Elsevier Science
Year
2012
Tongue
English
Weight
772 KB
Volume
30
Category
Article
ISSN
0264-410X

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✍ Koen Oosterhuis; Peter Öhlschläger; Joost H. van den Berg; Mireille Toebes; Raqu 📂 Article 📅 2011 🏛 John Wiley and Sons 🌐 French ⚖ 549 KB

To allow vaccination irrespective of HLA type, DNA vaccines encoding full-length antigens are required. However, here, we demonstrate that the immunogenicity of DNA vaccines encoding the full-length human papillomavirus (HPV) type 16 E7 and E6 proteins is highly reduced compared to vaccines encoding