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Modification of K+channel properties induced by fatty acids in neuroblastoma cells

✍ Scribed by Béatrice Rouzaire-Dubois; Valérie Gérard; Jean -Marc Dubois

Publisher
Springer
Year
1991
Tongue
English
Weight
519 KB
Volume
419
Category
Article
ISSN
0031-6768

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✦ Synopsis

The effects of fatty acids on voltage-dependent potassium (K § channels in neuroblastoma cells were studied using the whole-cell current recording technique. At a concentration of 5 ~tM, unsaturated and medium chain length (C10-C14) saturated fatty acids accelerated the apparent inactivation of the K + current. This effect was reversed by albumin. In the absence of exogenous fatty acids, albumin slowed the inactivation of the K + current. The acceleration of the K + current inactivation induced by unsaturated fatty acids was associated with an increase in the sensitivity of K + channels to 4-aminopyridine. It is concluded that kinetic and pharmacological properties of K + channels are, in part, controlled by membrane fatty acids which, in this way, should contribute to an apparent diversity of K + channels and the modulation of cell excitability.

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