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Modification of electrophysiological and pharmacological properties of K channels in neuroblastoma cells induced by the oxidant chloramine-T

✍ Scribed by Béatrice Rouzaire-Dubois; Jean -Marc Dubois

Publisher
Springer
Year
1990
Tongue
English
Weight
514 KB
Volume
416
Category
Article
ISSN
0031-6768

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✦ Synopsis

The effects of chloramine-T (CL-T) on voltagedependent potassium channels in neuroblastoma cells were analysed using the whole-cell current recording technique. CL-T irreversibly decreased the peak whole -cell K current, considerably slowed its inactivation and shifted its activation-voltage curve towards positive voltages by 6 inV. Under control conditions, the inactivation of the whole-cell K current could be described by the sum of two exponentials, F and S, whose time constants at +50 mV were TF = 1.00+ 0.

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