Subconductance states of single sodium channels modified by chloramine-T and sea anemone toxin in neuroblastoma cells

Chloramine-T effect on sodium conductanc

Chloramine-T effect on sodium conductance of neuroblastoma cells as studied by whole-cell clamp and single-channel analysis

✍ Petra Niemann; Johann Schmidtmayer; Werner Ulbricht 📂 Article 📅 1991 🏛 Springer 🌐 English ⚖ 776 KB

Patch-clamp experiments were done on sodium channels of neuroblastoma cells (N1E-115) in the presence of tetraethylammonium ions to block potassium channels. In Ringer solution whole-cell records revealed a diphasic INa inactivation with the fast (tau 0) component. being clearly larger than the slow