Modification of cell membrane in variants of chinese hamster cells resistant to abrin
โ Scribed by I-Chian Li; Diane A. Blake; Irwin J. Goldstein; Ernest H.Y. Chu
- Book ID
- 118877726
- Publisher
- Elsevier Science
- Year
- 1980
- Tongue
- English
- Weight
- 741 KB
- Volume
- 129
- Category
- Article
- ISSN
- 0014-4827
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## Abstract Abrin, a potent cytotoxin, was utilized as a probe to elucidate the mechanism by which external proteins are delivered to the cytoplasm of mammalian cells. Abrin bound rapidly to the surface receptors of the Chinese hamster cells (line CHO) and appeared to be internalized immediately wi
## Abstract Chinese hamster cells do not grow in medium containing high concentrations of adenosine because pyrimidine biosynthesis is inhibited. Adenosine metabolism was examined in two mutant cell lines isolated on the basis of resistance to adenosine. One line was deficient in adenosine kinase s