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Modification of alkylating agent cytotoxicity by cisplatin

โœ Scribed by Michael R. Horsman; David G. Hirs; Dennis M. Brown; J.Martin Brown


Book ID
103720880
Publisher
Elsevier Science
Year
1984
Tongue
English
Weight
547 KB
Volume
10
Category
Article
ISSN
0360-3016

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Nitrogen and sulfur analogues of the sec
โœ M. Tercel; W.A. Denny; W.R. Wilson ๐Ÿ“‚ Article ๐Ÿ“… 1996 ๐Ÿ› Elsevier Science ๐ŸŒ English โš– 282 KB

The first synthesis of seco-CI alkylating agents bearing a nitrogen or sulfur substituent in place of the oxygen at C-6 is described. In comparison with a phenol, an amino substituent confers reduced but significant cytotoxicity, even when mono-or dimethylated, while sulfur analogues are considerabl