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Docetaxel enhances the cytotoxicity of cisplatin to gastric cancer cells by modification of intracellular platinum metabolism

✍ Scribed by Shingo Maeda; Tsudoi Sugiura; Yoshiro Saikawa; Tetsuro Kubota; Yoshihide Otani; Koichiro Kumai; Masaki Kitajima

Book ID: 108583440
Publisher: John Wiley and Sons
Year: 2004
Tongue: English
Weight: 144 KB
Volume: 95
Category: Article
ISSN: 1347-9032
DOI: 10.1111/j.1349-7006.2004.tb03329.x

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## Abstract We have recently demonstrated in a Phase I/II study that combination chemotherapy with docetaxel (TXT) and S‐1 is active against metastatic gastric carcinomas. To elucidate the mechanisms underlying the synergistic effects of these drugs, both the growth inhibitory effects and the expre