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Nitrogen and sulfur analogues of the secoCI alkylating agent: Synthesis and cytotoxicity

✍ Scribed by M. Tercel; W.A. Denny; W.R. Wilson

Book ID
104364653
Publisher
Elsevier Science
Year
1996
Tongue
English
Weight
282 KB
Volume
6
Category
Article
ISSN
0960-894X

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✦ Synopsis

The first synthesis of seco-CI alkylating agents bearing a nitrogen or sulfur substituent in place of the oxygen at C-6 is described. In comparison with a phenol, an amino substituent confers reduced but significant cytotoxicity, even when mono-or dimethylated, while sulfur analogues are considerably less potent.

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