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Modification by curcumin of mutagenic activation of carcinogenic N-nitrosamines by extrahepatic cytochromes P-450 2B1 and 2E1 in rats

✍ Scribed by Yukio Mori; Kenjiro Tatematsu; Akihiro Koide; Shigeyuki Sugie; Takuji Tanaka; Hideki Mori

Book ID
108583698
Publisher
John Wiley and Sons
Year
2006
Tongue
English
Weight
506 KB
Volume
97
Category
Article
ISSN
1347-9032

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Cytochrome P-450 2E1 is a specific isozyme of cytochrome P-450 induced by ethanol. P-450 2E1 may also be the only enzyme that metabolizes N-nitrosodimethylamine at a very low concentration. Because N-nitrosodimethylamine is a procarcinogen, the possibility that induction of P-450 2El by alcohol abus