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n-6 and n-3 Polyunsaturated fatty acids down-regulate cytochrome P-450 2B1 gene expression induced by phenobarbital in primary rat hepatocytes

✍ Scribed by Chien-Chun Li; Chong-Kuei Lii; Kai-Li Liu; Jaw-Ji Yang; Haw-Wen Chen

Book ID
108187254
Publisher
Elsevier Science
Year
2006
Tongue
English
Weight
323 KB
Volume
17
Category
Article
ISSN
0955-2863

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Docosahexaenoic acid downregulates phenobarbital-induced cytochrome P450 2B1 gene expression in rat primary hepatocytes via the c-Jun NH2-terminal kinase mitogen-activated protein kinase pathway
✍ Chia-Yang Lu; Chien-Chun Li; Kai-Li Liu; Chong-Kuei Lii; Haw-Wen Chen 📂 Article 📅 2009 🏛 John Wiley and Sons 🌐 English ⚖ 840 KB

## Abstract Mitogen‐activated protein kinase (MAPK) pathways play central roles in the transduction of extracellular stimuli into cells and the regulation of expression of numerous genes. Docosahexaenoic acid (DHA) was shown to be involved in the regulation of expression of drug metabolizing enzyme