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Modeling age of onset and residual familial correlations for the linkage analysis of bipolar disorder

✍ Scribed by Audrey H. Schnell; P. Mahinda Karunaratne; John S. Witte; Deborah V. Dawson; Robert C. Elston

Publisher: John Wiley and Sons
Year: 1997
Tongue: English
Weight: 47 KB
Volume: 14
Category: Article
ISSN: 0741-0395
DOI: 10.1002/(sici)1098-2272(1997)14:6<675::aid-gepi21>3.0.co;2-m

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✦ Synopsis

We applied regressive modeling to the data described by Stine et al. [1995] and further explored the possible linkage of bipolar disorder to marker D18S41 on chromosome 18. We performed analyses to determine age-dependent penetrance functions that best fit the data and that allow for residual familial correlations. Specifically, we introduce here a simple method to allow for a sibling correlation that is not due to segregation at the linked locus, and then extend the results of Stine et al. [1995] by using the best fitting "regressive" model of this kind as input into a lod score linkage analysis. Although a formal segregation analysis was not attempted, a surprising finding was that, except for doubtful linkage to D18S41, there is little evidence for genetic transmission of bipolar disorder in these families.

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