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Model-free age-of-onset methods applied to the linkage of bipolar disorder

✍ Scribed by Xiaofeng Zhu; Jane M. Olson; Audrey H. Schnell; Robert C. Elston

Publisher: John Wiley and Sons
Year: 1997
Tongue: English
Weight: 37 KB
Volume: 14
Category: Article
ISSN: 0741-0395
DOI: 10.1002/(sici)1098-2272(1997)14:6<711::aid-gepi27>3.0.co;2-s

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✦ Synopsis

We performed Haseman-Elston regression on a set of bipolar pedigrees using each of three dependent variables: a binary trait indicating disease concordance or discordance, a binary trait adjusted for age-of-onset, and the residuals from a survival analysis. The latter two methods, which both adjust for age-of-onset, gave smaller p-values when previous analyses suggested linkage between disease and marker, but not when previous analyses were not suggestive of linkage.

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