We applied regressive modeling to the data described by Stine et al. [1995] and further explored the possible linkage of bipolar disorder to marker D18S41 on chromosome 18. We performed analyses to determine age-dependent penetrance functions that best fit the data and that allow for residual famili
Age of first onset of bipolar disorder: Demographic, family history, and psychosocial correlates
β Scribed by Judith C. Hays; K. Ranga R. Krishnan; Linda K. George; Dan G. Blazer
- Publisher
- John Wiley and Sons
- Year
- 1998
- Tongue
- English
- Weight
- 80 KB
- Volume
- 7
- Category
- Article
- ISSN
- 1091-4269
No coin nor oath required. For personal study only.
β¦ Synopsis
The literature suggests that bipolar elders with early and late onset of the disorder present with different demographic, family history, and psychosocial profiles, which are less well characterized than those for elderly unipolar patients. In this cross-sectional clinical survey, we assessed subjects (n = 74) from the NIMH Clinical Research Center for the Study of Depression in Later Life at Duke University who had a consensus diagnosis of bipolar depression; the primary assessment instrument was the Duke Depression Evaluation Schedule. We found that bipolar subjects with later age of onset reported less family history of psychiatric problems, more comorbid vascular disease, and more instrumental and subjective social support. Stressful life events were more frequent among bipolar subjects with earlier age of depressive symptom onset. This study suggests that early-onset disorder may be characterized by a psychosocial component, whereas organic factors may be particularly important to late-onset bipolar disorder.
π SIMILAR VOLUMES
We performed Haseman-Elston regression on a set of bipolar pedigrees using each of three dependent variables: a binary trait indicating disease concordance or discordance, a binary trait adjusted for age-of-onset, and the residuals from a survival analysis. The latter two methods, which both adjust
Genome-wide association studies (GWAS) have identified several susceptibility loci for bipolar disorder (BP), most notably ANK3. However, most of the inherited risk for BP remains unexplained. One reason for the limited success may be the genetic heterogeneity of BP. Clinical sub-phenotypes of BP ma
Expressed emotion (EE) is discussed in relation to bipolar affective disorder, a major psychiatric illness involving fluctuating periods of mania and depression. High levels of EE among relatives of bipolar clients are conceptualized as reactions to the stress of adjusting to the acute illness perio
The discovery of expanding microsatellite repeat mechanisms for a variety of diseases has spurred renewed interest in testing for genetic anticipation in complex diseases. However, standard statistical methods can be shown to be inappropriate for this purpose. We derive a new statistical test for co