## Abstract We present a model to describe the equilibrium binding properties for the attachment of multivalent ligands to mobile receptors in membranes. The interaction is assumed to be governed by two inherently different association constants. The first of these controls the initial attachment o
Model and Simulation of Multivalent Binding to Fixed Ligands
✍ Scribed by Kristian M. Müller; Katja M. Arndt; Andreas Plückthun
- Publisher
- Elsevier Science
- Year
- 1998
- Tongue
- English
- Weight
- 411 KB
- Volume
- 261
- Category
- Article
- ISSN
- 0003-2697
No coin nor oath required. For personal study only.
📜 SIMILAR VOLUMES
In an effort to find highly efficient ligands for hepatic asialoglycoprotein receptor (ASGPR), four cluster galactosides with different scaffolds were synthesized in this paper. The affinity of these compounds for ASGPR was analyzed by binding study in vitro. The results showed that trivalent cluste
A new statistical procedure is described which permits the direct, quantitative comparison of alternative physical models for a set of experimental results. Its reliability is demonstrated through a computer simulation study, and its usefulness is illustrated in the analysis of nonlinear van? Hoff a
A ligand binding model of counterion association in finite length polyelectrolytes is presented. This model introduces counterion condensation features into a binding formalism. It agrees well with the predictions of other finite length models and is consistent with experimental data on helix-coil m
## Abstract β‐Cyclodextrin (β‐CD) monolayers have been immobilized in microchannels. The host–guest interactions on the β‐CD monolayers inside the channels were comparable to the interactions on β‐CD monolayers on planar surfaces, and a divalent fluorescent guest attached with a comparable binding