𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Design of Multivalent Galactoside Ligands and Their Binding to Hepatic Asialoglycoprotein Receptor

✍ Scribed by Xiao-Ru Zhang; Ji-Long Jia; Rong-Jun Zhang; Min-Hua Xu; Shu-Sheng Zhang

Publisher
John Wiley and Sons
Year
2006
Tongue
English
Weight
62 KB
Volume
24
Category
Article
ISSN
0256-7660

No coin nor oath required. For personal study only.

✦ Synopsis

In an effort to find highly efficient ligands for hepatic asialoglycoprotein receptor (ASGPR), four cluster galactosides with different scaffolds were synthesized in this paper. The affinity of these compounds for ASGPR was analyzed by binding study in vitro. The results showed that trivalent cluster galactosides behaved better than divalent analogues and the cluster galactosides with aryl groups on their scaffolds presented better binding affinity than those with aliphatic chain scaffolds.

πŸ“œ SIMILAR VOLUMES

Complement-mediated cytotoxicity and inh
Complement-mediated cytotoxicity and inhibition of ligand binding to hepatocytes by woodchuck hepatitis virus–induced autoantibodies to asialoglycoprotein receptor
✍ Jingyu Diao; Norma D. Churchill; Tomasz I. Michalak πŸ“‚ Article πŸ“… 1998 πŸ› John Wiley and Sons 🌐 English βš– 226 KB

Hepadnavirus invasion in woodchucks has been identified as a potent inducer of autoantibodies against asialoglycoprotein receptor (anti-ASGPR), a molecule essentially unique to hepatocytes that mediate clearance of desialylated serum proteins. We evaluated the possible pathogenetic importance of ant