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Mode of Action of Gentamicin Antibiotics Produced by Micromonospora purpurea

โœ Scribed by Abou-Zeid, A.A.; Eissa, A.I.; Salemi, H.M.

Book ID
122968412
Publisher
Elsevier
Year
1978
Weight
926 KB
Volume
133
Category
Article
ISSN
0323-6056

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Methylation of 16S ribosomal RNA and res
Methylation of 16S ribosomal RNA and resistance to the aminoglycoside antibiotics gentamicin and kanamycin determined by DNA from the gentamicin-producer, Micromonospora purpurea
โœ Thompson, Jill ;Skeggs, Patricia A. ;Cundliffe, Eric ๐Ÿ“‚ Article ๐Ÿ“… 1985 ๐Ÿ› Springer ๐ŸŒ English โš– 598 KB

When DNA fragments from Micromonospora purpurea (the producer of gentamicin) were cloned in Streptomyces lividans, a gentamicin-resistant strain was obtained in which the ribosomes were highly resistant both to gentamicin and to kanamycin. Reconstitution analysis revealed that such resistance result