✦ LIBER ✦

MLR3 molecule is an activation antigen shared by human B, T lymphocytes and T cell precursors

✍ Scribed by Angela Risso; Maria Elisabetta Cosulich; Anna Rubartelli; Maria Rosaria Mazza; Antonio Bargellesi

Publisher: John Wiley and Sons
Year: 1989
Tongue: English
Weight: 714 KB
Volume: 19
Category: Article
ISSN: 0014-2980
DOI: 10.1002/eji.1830190216

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✦ Synopsis

MLR3 molecule is an activation antigen shared by human B, T lymphocytes and T cell precursors*

MLR3 molecule is a membrane glycoprotein (mol. mass range 28-34 kDa) present on activated, but not resting human peripheral T cells, B cells and thymocytes. Its kinetics of appearance on the cell surface (3 h after the addition of the inductive signal to the cells) suggests that it is an early activation antigen. The proliferative response of cultured T and B lymphocytes and thymocytes to different activation signals is inhibited by the addition of MLR3 monoclonal antibody. Moreover the antibody in combination with non-mitogenic doses of phorbol myristate acetate leads to proliferation of thymocytes and resting B and T lymphocytes. In the latter, synthesis of interleukin 2 is also induced. Biochemical analysis of MLR3 antigen indicates that it is a phosphorylated protein with N-linked sugar moieties. Together these data suggest a role for MLR3 antigen in the signal transduction process during activation, both for mature lymphocytes and for T cell precursors.

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