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MLL partial tandem duplications in acute leukemia cell lines

✍ Scribed by Quentmeier, H; Reinhardt, J; Zaborski, M; Drexler, H G


Book ID
110055457
Publisher
Nature Publishing Group
Year
2003
Tongue
English
Weight
95 KB
Volume
17
Category
Article
ISSN
0887-6924

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## Abstract Partial tandem duplication (PTD) of the __MLL__ gene and internal tandem duplication (ITD) of the juxtamembrane region of the __FLT3__ receptor tyrosine kinase gene have been described in acute myeloid leukemia (AML) patients, preferentially in those with normal cytogenetics. These alte

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## Abstract __MLL__ (also known as __ALL‐1, HTRX__, or __HRX__) gene translocations are among the most common chromosomal abnormalities recognized in both B‐lineage acute lymphoblastic leukemia (ALL) and acute myeloid leukemia (AML). However, __MLL__ gene rearrangements are uncommon in T‐cell ALL.